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Aspirin

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The Wonders Of Bayer Aspirin Biology Essay

Today, there are many medicines used to treat human diseases and one of the medicines is called Bayer aspirin. Aspirin (acetylsalicylic acid) is a white or colourless crystalline powder. Anthony (2002). It is used to treat mainly minor pains, but has their benefits like lowering fever, inflammation, and reduces blood from clotting. The trade name of aspirin is Bayer and the chemical name is acetylsalicylic acid. The manufacture name is time cap laboratories Inc that produces aspirin. Bayer aspirin contains both active and inactive ingredients. In each tablet the active ingredient is acetylsalicylic acid. Other than the active ingredients other components are the inactive ingredient. Now I will be mentioning the absorption, mode of administration, mechanism of action and the elimination of aspirin.
Figure 1 Chemical structure of aspirin. The above structure shows a benzene ring which is an aromatic compound. It also shows that acetylsalicylic acid is an ester and a carboxylic acid. However, there isn’t a phenol group. Both carboxylic acid and ester doesn’t reacts with phenol. Aspirin has the chemical formula of C9H8O4. Adapted from: http://cancerpreventiontheory.info/aspirin.jpg Absorption
A drug wouldn’t be effective if the human body doesn’t breakdown and absorb the drug easily. When the aspirin enters the stomach some of it absorbs within the stomach as the aspirin is acetylsalicylic acid and the stomach contains acid. Anthony (2002). In the stomach (pH 2) the hydrolysis rate is lower than at pH 9-11 that is found in the upper G.I tract as the rate goes up significantly. Not all aspirin is absorbed in the stomach as it is a weak acid, but most of the absorption occurs in the upper part of the small intestine by passive diffusion. Aschenbrenner and Samantha (2009). The reason that less absorption occurs in the stomach is due to the surface area of the mucosa in the stomach and the coating layer that is on the tablet. Rainsford (2004). In the stomach about 24% of aspirin is ionised. About 10 minutes and after in the stomach the mass of the aspirin roughly about 12% is absorbed from a solution that is un-buffered. Cooke and Hunt. (1970). If the pH of gastric has risen up to pH 6 there would be a decrease about 1% of the area of absorption as the majority of aspirin would then be in a less permeable ionised form. Slower gastric absorption which is due to increased pH isn’t reflected in the overall slower absorption. This is because the solution that is buffered is rapidly removed into the upper part of the gastrointestinal tract and here the rate of absorption is fast. Dotevall and Ekenved (1976). The rate of absorption of aspirin salts is quick in a man on an empty stomach having a half life of absorption about 5-16 minutes. Rowland et al. (1972).…...

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